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Image Search Results
Journal: Glycoconjugate Journal
Article Title: Molecular expression of glycosaminoglycans modifies the plasticity of biphasic mesothelioma in favor of tumor progression
doi: 10.1007/s10719-025-10192-z
Figure Lengend Snippet: Histological illustration of epithelioid malignant pleural mesothelioma (E-MPM) and biphasic MPM (B-MPM) tissues. Examples of E-MPM and B-MPM subtypes as defined by heparan sulfate, chondroitin sulfate, versican, byglican, and perlecan expression. Two types of regions are represented based on areas with high expression levels of glycosaminoglycan GAG markers. E-MPM and B-MPM corresponded to areas of pure E- and B- components, respectively. As is shown in Table , low expression levels of chondroitin sulfate and versican were observed in epithelioid cells from E-MPM tumors. Heparan sulfate and byglican were positively expressed by fusiform cells in B-MPM tumors, contrasting with weak expression in E-MPM tumors and E- areas of B-MPM ones. Perlecan expression indicated high levels of GAG markers in both E-MPM and B-MPM tumors. Magnification: 400×. Scale: 50 μm. *** P < 0.001, **** P < 0.0001. The red square in the boxplots represents the mean value of the data
Article Snippet: The slides were stained with immunoperoxidase and antibodies against heparan sulfate (1:100; AMSBIO LLC, #370255-1, clone F58-10E4), chondroitin sulfate (1:200; Sigma-Aldrich, #C8035, clone CS-56),
Techniques: Expressing
Journal: Glycoconjugate Journal
Article Title: Molecular expression of glycosaminoglycans modifies the plasticity of biphasic mesothelioma in favor of tumor progression
doi: 10.1007/s10719-025-10192-z
Figure Lengend Snippet: Spearman correlation matrix of glycosaminoglycans, proteoglycans, and extracellular matrix (ECM) proteins in malignant pleural mesothelioma tissue samples. The illustration shows the Spearman correlation coefficients (ρ) - represented by the circles, that when larger, the values closer to|1| (i.e., a stronger correlation). Positive correlations are shown in blue (stronger intensity indicates higher correlation), while negative correlations are shown in orange. Statistically significant moderate positive correlations were observed between HS and CS, HS and versican, HS and biglycan, HS and perlecan, versican and biglycan, versican and elastin, and biglycan and elastin. A moderate inverse correlation was noted between perlecan and collagen V. * P < 0.05; ** P < 0.01
Article Snippet: The slides were stained with immunoperoxidase and antibodies against heparan sulfate (1:100; AMSBIO LLC, #370255-1, clone F58-10E4), chondroitin sulfate (1:200; Sigma-Aldrich, #C8035, clone CS-56),
Techniques:
Journal: Glycoconjugate Journal
Article Title: Molecular expression of glycosaminoglycans modifies the plasticity of biphasic mesothelioma in favor of tumor progression
doi: 10.1007/s10719-025-10192-z
Figure Lengend Snippet: Kaplan–Meier overall survival analysis according to extracellular matrix component expression in malignant pleural mesothelioma patients. Kaplan–Meier survival curves comparing overall survival (OS) between patients stratified by high and low immunohistochemical expression levels of ( A ) heparan sulfate, ( B ) chondroitin sulfate, ( C ) versican, ( D ) biglycan, and ( E ) perlecan. Patients were dichotomized based on median expression cutoffs for each marker. No statistically significant differences in OS were observed between the groups using the log-rank test
Article Snippet: The slides were stained with immunoperoxidase and antibodies against heparan sulfate (1:100; AMSBIO LLC, #370255-1, clone F58-10E4), chondroitin sulfate (1:200; Sigma-Aldrich, #C8035, clone CS-56),
Techniques: Expressing, Immunohistochemical staining, Marker